To appraise the validity of the evidence for a clinical question, it is necessary to consider both the study design and the methodological quality of the study. <>/BS<>/F 4/Rect[256.49 690.8 336.93 703.01]/Subtype/Link>> Defining Applicability 0000002698 00000 n 3Department for Evidence-based Medicine and Clinical Epidemiology, Danube University, Krems, Austria. 49 0 obj Instead, they provide a menu of techniques that should be critically chosen based on research paradigm, design, purpose, questions, and context. 0000001136 00000 n Moreover, as noted inStep 2, no single study design can answer all types of PICO questions.